Core and Foundational Pharmaceutical Sciences
- Physical pharmacy, preformulation, and solid-state chemistry
- Medicinal chemistry: target ID/validation, hit finding, SAR, lead optimization
- Chemical biology & chemoproteomics
- Biopharmaceutics & BCS/BDDCS; permeability, solubility, dissolution
- Natural Product Chemistry & Bioprospecting
- Biostatistics for bench scientists (design of experiments, power, error control)
Pharmaceutical progress begins with a solid understanding of the physical, chemical, and biological principles that govern how medicines are designed, formulated, and delivered. Core & Foundational Pharmaceutical Sciences provides the essential base for every professional involved in research, manufacturing, and quality assurance. This session examines how physical pharmacy, medicinal chemistry, biopharmaceutics, and chemical biology interact to determine drug performance—from solubility and stability to bioavailability and therapeutic efficacy. By integrating these disciplines, scientists can optimize molecular properties early, predict behavior in physiological environments, and improve success rates throughout development.
Participants will explore structure–activity relationships, solid-state characterization, and the use of predictive modeling tools to inform preformulation and formulation design. The session also introduces current advances in analytical methods that link molecular data to dosage-form performance. Attendees will understand how pH partitioning, permeability, and dissolution kinetics influence clinical outcomes and regulatory expectations. Special emphasis is placed on data integrity and reproducibility in basic experiments, ensuring that foundational work supports downstream CMC and clinical stages.
For scientists, educators, and early-career researchers seeking a Pharma Conference, this session offers a deep dive into experimental design, biostatistics, and quality-by-design (QbD) frameworks. It also addresses trends such as automation in early screening, molecular simulations, and machine-assisted property prediction that are redefining laboratory workflows. The knowledge shared here enables professionals to build a robust scientific foundation for discovery and development pipelines. Whether you focus on formulation, analytical chemistry, or process design, understanding these fundamentals ensures every innovation is built on reliable science.
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Essential Concepts and Quick Wins
Preformulation & Solid State
- Polymorph and salt/co-crystal selection strategies that stabilize the active and improve exposure.
- Hygroscopicity, flow, and compaction insights that prevent downstream manufacturing surprises.
Biopharmaceutics & BCS/BDDCS
- Solubility–permeability mapping to choose viable routes and enabling formulations.
- Biorelevant dissolution and IVIVC considerations to anticipate clinical performance.
Developability-Aware Medicinal Chemistry
- Tuning lipophilicity, ionization, and HBD/HBA balance to improve ADME and manufacturability.
- Early safety/off-target flag reduction informed by chemoproteomics and in silico screening.
Statistics for Bench Scientists
- Right-sized DoE that accelerates learning while controlling Type I/II error.
- Power, replication, and data hygiene practices that make results robust and reusable.
Protein & Peptide Fundamentals
- Aggregation and degradation mechanisms with practical stabilization levers.
- Buffer, pH, and excipient choices aligned to target product profile and shelf life.
Early Manufacturability Signals
- Particle-size and morphology control aligned to flow and compressibility needs.
- Excipient compatibility checks that prevent incompatibilities at scale.
How This Session Delivers Impact
De-Risking R&D
Applies fundamental data to reduce late-stage failures and rework.
Faster with Rigor
Uses fit-for-purpose statistics to shorten cycles without cutting corners.
Dose Feasibility
Links permeability/solubility to human exposure and realistic dosing routes
Better Methods
Builds stability-indicating, scale-aware analytical strategies early.
Cross-Modality Readiness
Translates principles from small molecules to peptides and proteins.
Teaching & Standardization
Creates a common language for teams and internal academies.
Inspection-Ready Data
Strengthens documentation, traceability, and reproducibility from day one.
Seamless Handoffs
Improves interfaces between discovery, preformulation, and CMC.
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